QED Bioscience/FIG4/56584/1 Ea
FIG4 Monoclonal Antibody
ORDERING INFORMATION
Catalog no.: 56584 (clone S202-7)
Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.
BACKGROUND
The protein encoded by the FIG4 gene belongs to the SAC domain-containing protein gene family. The SAC domain has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Diseases associated with FIG4 include Polymicrogyria, Bilateral Temporooccipital and Charcot-Marie-Tooth Disease, Type 4J.
SPECIFICATION SUMMARY
Antigen: Fusion protein corresponding to aa 688-907 (C-terminus) of mouse FIG4. This sequence is 95% identical in rat and 91% identical in human.
Accession nos: NP_598760.1, Q91WF7
Gene ID: 103199
Host Species: Mouse
Antibody Class: IgG1
Specificity: This antibody recognizes human, mouse, and rat FIG4.
APPLICATIONS
Immunoblotting: use at 1-5ug/ml. A band of
~100kDa is detected.
Immunofluorescence: use at 10ug/ml.
Detection of FIG4 in mouse brain lysate with
#56584 at 5ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their application.
Detection of FIG4 in neuroblastoma cell line SK- N-BE with #56584 at 10ug/ml: DAPI (blue) nuclear stain, Texas Red F actin stain, ATTO 488 (green) FIG4 stain.
DILUTION INSTRUCTIONS
Dilute in PBS or medium that is identical to that used in the assay system.
FIG4 Monoclonal Antibody
STORAGE AND STABILITY
This product is stable for at least one (1) year at -20oC.
For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures.
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