Description: Integrin alpha-IIb (CD41), Human, mAb Q90

Monoclonal antibody Q90 recognizes human CD41, also called ITGA2B, GPIIb or integrin alpha chain 2b. It is predominantly expressed on platelets and plays a pivotal role in coagulation. CD41 associates with integrin β3 chain (GPIIa or CD61) to form the CD41/CD61 complex. This complex is a receptor for fibrinogen, vWF, fibronectin, vitronectin, thrombospondin, prothrombin and thrombospondin. The integrin receptor is required for platelet adhesion and aggregation. Per platelet there are approximately 60-80 thousand copies of the complex. CD41 has been considered a biomarker for megakaryocytes. Although there is increasing evidence that it also expressed during early hematopoiesis with low expression levels on cells with myeloid and lymphoid potential. Given its central role in haemostasis it has been considered an anti-thrombotic target with alternating success. Mutations in the genes of the CD41/CD61 complex are a cause of Glanzmann thrombasthenia leading to bleeding disorders. Furthermore, there are some associations with tumor metastasis.

Specifications:

Catalog number Product type Quantity Formulation Application Application Notes Use Immunogen Isotype Species Alias Storage and stability Precautions Disease

HM2343

Monoclonal antibodies

100 µg

1 ml (100 μg/ml) 0.2 μm filtered antibody solution in PBS, containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Frozen sections, Paraffin sections, Western blot

W: A reduced sample treatment and SDS-Page was used. The band size is 120 kDa.

Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Synthetic CD41 peptide

Mouse IgG1

Human

ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41

Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.

Cardiology and metabolism, Tumor immunology