Description: Lipid A, mAb 26-5

The monoclonal antibody 26-5 recognizes lipid A. The lipid A domain of lipopolysaccharide (LPS) is aunique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane ofmost gram-negative bacteria.Lipid A is responsible for the endotoxic activities of LPS, and a heteropolysaccharide. Theheteropolysaccharide generally consists of an oligosaccharide termed the core region. This core regionis in some bacterial families composed of repeating oligosaccharide units, the so-called O chain. Thelipid A moiety of LPS is detected by the TLR4/MD2 receptor of the mammalian innate immune system.Picomolar levels of lipid A induce macrophages to synthesize potent mediators of inflammation, such asTNF-α and IL-1β. Furthermore, lipid A activates the production of costimulatory molecules required foradaptive immunity and stimulates tissue factor production in mononuclear and endothelial cells. Allthese events are desirable for clearing local infections.

Specifications:

Catalog number Product type Quantity Formulation Application Isotype Species References Storage and stability Precautions Disease

HM6009

Monoclonal antibodies

100 µg

1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.

Immuno assays

Mouse IgG2b

N/A

Erich, T et al; Binding characteristics and cross-reactivity of three different antilipid A monoclonal antibodies. J of Immunol 1989, 143: 4053

Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year.

For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.

Infectious diseases