Description
Actinoninisaninhibitorofpeptidedeformylase,matrixmetalloproteinasemeprinA,andaminopeptidaseN(CD13).Actinoninexhibitsanticancer,antibiotic,anti-inflammatory,andnephroprotectiveactivities.InBurkitt’slymphomacells,actinonininhibitsmitochondrialproteintranslation,inducingapoptosis.Actinoninexhibitsantibacterialefficacyagainstmanygramnegativebacteria,includingMycobacterium.Additionally,inanimalmodelsofcecalligationandpuncture,actinonindecreaseslevelsofIL-1β,preservingrenalmorphologyandpreventingalterationsinrenalcapillaryprofusionandsepsis.
References
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