
- SpeciesReactivityHuman
- SpecificityDetectshumanCalciumActivatedNucleotidase1/CANT1inELISAs.
- SourceMonoclonalMouseIgG1Clone#861206
- PurificationProteinAorGpurifiedfromhybridomaculturesupernatant
- ImmunogenMousemyelomacelllineNS0-derivedrecombinanthumanCalciumActivatedNucleotidase1/CANT1
Gly80-Ile401
Accession#Q8WVQ1 - FormulationLyophilizedfroma0.2μmfilteredsolutioninPBSwithTrehalose.*Smallpacksize(SP)issuppliedasa0.2µmfilteredsolutioninPBS.
- LabelUnconjugated
- WesternBlot2µg/mLSeebelow
- SimpleWestern20µg/mLSeebelow
- Immunocytochemistry8-25µg/mLSeebelow
- ReconstitutionSterilePBStoafinalconcentrationof0.5mg/mL.
- ShippingTheproductisshippedatambienttemperature.Uponreceipt,storeitimmediatelyatthetemperaturerecommendedbelow.*Smallpacksize(SP)isshippedwithpolarpacks.Uponreceipt,storeitimmediatelyat-20to-70°C
- StABIlity&StorageUseamanualdefrostfreezerandavoidrepeatedfreeze-thawcycles.
- 12monthsfromdateofreceipt,-20to-70°Cassupplied.
- 1month,2to8°Cundersterileconditionsafterreconstitution.
- 6months,-20to-70°Cundersterileconditionsafterreconstitution.
- LongName:SolubleCalciumActivatedNucleotidase1
- EntrezGeneIDs:124583(Human);76025(Mouse);246272(Rat)
- AlternateNames:Apyrasehomolog;calciumactivatednucleotidase1;CANT1;DBQD;EC3.6.1.6;PutativeMAPK-activatingproteinPM09;PutativeNF-kappa-B-activatingprotein107;SCAN1;SCAN-1Ca2+-dependentendoplasmicreticulumnucleosidediphosphatase;SHAPY;SHAPYmicromelicdwarfismwithvertebralandmetaphysealabnormalitiesandadvancedcarpotarsalossification;solubleCa-activatednucleotidase,isozyme1;solublecalcium-activatednucleotidase1;solublecalcium-activatednucleotidaseSCAN-1
Background:
CANT1(solubleCalcium-ActivatedNucleoTidase1;alsoSCAN-1,ApyrasehomologandNFkappaB-activatingprotein107)isa45-48kDaglycoproteinmemberoftheapyrase(ADP/ATPhydrolysing)familyofmolecules.ItisanERandGolgi-embeddedproteinthathydrolyzesUDPinacalcium-dependentmanner,andappearstobeinvolvedintheregulationofproteinglycosylationandfolding.ItisalsoreportedthatCANT1isessentialforcellproliferation.CANT1isnotubiquitous,butisfoundinmultiplecelltypes,includingprostaticepithelium,fibroblasts,lymphocytesandchondrocytes.HumanCANT1isa401aminoacid(aa)typeIItransmembraneglycoprotein.Itcontainsa44aaN-terminalcytoplasmicregionthatpossessesanERretentionmotif(aa38-42),anda339aaluminaldomain(aa63-401).CANT1isreportedtoformmembrane-bounddisulfide-linkedhomodimers,andpotentiallyformsnon-covalenthomodimersinasoluble(circulating)state.Thesolubleformis35‑40 kDainsize,andpresumablycleavednearthetransmembranesegment.However,multiplespliceformsarepossIBLe,andmayaccountforthelowerMWs.Twospliceformsimpacttheextracellularregion,onewhichcontainsafouraasubstitutionforaa219-401,andasecondthatpossessesa26aasubstitutionforaa 220‑401.TwoadditionalspliceformsutilizealternativestartsitesatMet31andMet165.Overaa80-401,humanCANT1shares89%aasequenceidentitywithmouseCANT1.
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