BiologicalActivity
Potent,selectiveandcell-permeablec-Raf1kinaseinhibitor(IC50=9nM).Displays≥100-foldselectivityforrafkinaseoverCDK1,CDK2,c-src,ERK2,MEK,p38,Tie2,VEGFR2andc-fm.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoWellcomeIncandGlaxoGroupLtd.
TechnicalData
| M.Wt | 520.94 |
| Formula | C15H8Br2INO2 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 220904-83-6 |
| PubChemID | 5924208 |
| InChIKey | LMXYVLFTZRPNRV-KMKOMSMNSA-N |
| Smiles | OC1=C(Br)C=C(C=C2/C(=O)NC3=CC=C(I)C=C23)C=C1Br |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mMinethanolandto100mMinDMSO |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight520.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.92mL | 9.6mL | 19.2mL |
| 5mM | 0.38mL | 1.92mL | 3.84mL |
| 10mM | 0.19mL | 0.96mL | 1.92mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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