MedKooCat#:201880
Name:Milataxel
CAS#:393101-41-2
ChemicalFormula:C44H55NO16
ExactMass:853.35208
MolecularWeight:853.9
ElementalAnalysis:C,61.89;H,6.49;N,1.64;O,29.98
Synonym:MAC-321;MAC321;MAC321;TL-139;TL-139;TL-139;Milataxel
IUPAC/ChemicalName:(2aR,4S,4aS,6R,9S,11S,12S,12bS)-12b-acetoxy-9-(((2R,3R)-3-((tert-butoxycarbonyl)amino)-3-(furan-2-yl)-2-hydroxypropanoyl)oxy)-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(propionyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-ylbenzoate
InChiKey:XIVMHSNIQAICTR-DMUFGCTNSA-N
InChiCode:InChI=1S/C44H55NO16/c1-10-29(47)58-27-19-28-43(21-56-28,60-23(3)46)34-36(59-37(51)24-15-12-11-13-16-24)44(54)20-26(22(2)30(41(44,7)8)32(48)35(50)42(27,34)9)57-38(52)33(49)31(25-17-14-18-55-25)45-39(53)61-40(4,5)6/h11-18,26-28,31-34,36,48-49,54H,10,19-21H2,1-9H3,(H,45,53)/t26-,27-,28+,31-,32+,33+,34?,36-,42+,43-,44+/m0/s1
SMILESCode:O=C(O[C@@H]1C(C)=C(C2(C)C)[C@@H](O)C([C@@]([C@@H](OC(CC)=O)C3)(C)C([C@@]4(OC(C)=O)[C@]3([H])OC4)[C@H](OC(C5=CC=CC=C5)=O)[C@]2(O)C1)=O)[C@H](O)[C@@H](NC(OC(C)(C)C)=O)C6=CC=CO6
TechnicalData
AdditionalInformation
Milataxelisanorallybioavailabletaxanewithpotentialantineoplasticactivity.Uponoraladministration,milataxelanditsmajoractivemetaboliteM-10bindtoandstabilizetubulin,resultingintheinhibitionofmicrotubuledepolymerizationandcelldivision,cellcyclearrestintheG2/Mphase,andtheinhibitionoftumorcellproliferation.Unlikeothertaxanecompounds,milataxelappearstobeapoorsubstrateforthemultidrugresistance(MDR)membrane-associatedP-glycoprotein(P-gp)effluxpumpandmaybeusefulfortreatingmultidrug-resistanttumors.Checkforactiveclinicaltrialsorclosedclinicaltrialsusingthisagent.(NCIThesaurus).
Currentdeveloper:
References
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目前，CRISPR-Cas9系统的高效基因组编辑功能已被应用于多种生物，包括小鼠、大鼠、斑马鱼、秀丽隐杆线虫，也包含多种细菌和植物，甚至在人体上也有应用。
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D,K2SO4Na2CO3BaCL2NaNO3
C.MgCl2溶液和氨水D.盐酸和NaAlO2溶液
为什么
2.NaHCO3,Ba(OH)3,H2SO4
3.HCL,NaAlO2,NaHSO4
4.Ca(OH)2,Na2CO3,BaCO3
谢谢了
要原因
通过解答，教会我，谢谢
