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Tocris/Melphalan/4619/50/50 mg
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Tocris/Melphalan/4619/50/50 mg
品牌 / 
Tocris
货号 / 
4619/50
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4000-520-616
Description:DNAalkylatingagent;cytotoxicandantineoplastic
ChemicalName:4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DNAalkylatingagent;inducescytotoxicitythroughtheformationofstableinterstrandandintrastrandcrosslinkswithinDNA.InhibitsgrowthofPC-3cells(IC50valuesare0.074and0.77μg/mlforsequentialdosingandsingledosingrespectively).

TechnicalData

M.Wt305.2
FormulaC13H18Cl2N2O2
StorageStoreatRT
Purity≥95%(HPLC)
CASNumber148-82-3
PubChemID460612
InChIKeySGDBTWWWUNNDEQ-LBPRGKRZSA-N
SmilesClCCN(CCCl)C1=CC=C(C[C@H](N)C(O)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl6.120
DMSO6.120

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight305.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.28mL16.38mL32.77mL
5mM0.66mL3.28mL6.55mL
10mM0.33mL1.64mL3.28mL
50mM0.07mL0.33mL0.66mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet