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Description:PotentGPR37andGPR37L1agoNIST
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentGPR37L1andGPR37agonist(EC50valuesare5and7nM,respectively).Stimulatessignalingthroughpertussistoxin-sensitiveGproteins.StimulatesERKphosphorylation.Protectsagainstcellularstress.PromotesmyelinlipidsynthesisandprolongscellsurvivalinbothSchwanncellsandoligodendrocytes;neuroprotectiveandglioprotective.
TechnicalData
M.Wt | 1579.72 |
Formula | C69H110N16O26 |
Sequence | TXLIDNNATEEILY (Modifications:Ala-2=D-Ala) |
Storage | Storeat-20°C |
CASNumber | 196391-82-9 |
PubChemID | 16197909 |
InChIKey | SMUKRAODILXPSW-SRWCCNGVSA-N |
Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solubility | Solubleto2mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1579.72.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.63mL | 3.17mL | 6.33mL |
5mM | 0.13mL | 0.63mL | 1.27mL |
10mM | 0.06mL | 0.32mL | 0.63mL |
50mM | 0.01mL | 0.06mL | 0.13mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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