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Description
Details
Description:Mouse monoclonal antibody to human S100A7 (psoriasin)
Purification:Protein G affinity purified
Product Type: Primary antibody
Target Protein:Human S100A7 (psoriasin)
Immunogen:A short peptide (tdyhkqshgaapcsggs) derived from human S100A7 (psoriasin) was conjugated with KLH for immunization.
Fusion Myeloma:Sp2/0-Ag14
Specificity:This antibody is reactive to S100A7 peptide (tdyhkqshgaapcsggs) and GST tagged recombinant S100A7 protein.
Species Reacitvity:Human, others not tested
Host / Isotype:Mouse, IgG1 Kappa
Formulation:Lyophilized from a solution in 0.01M PBS, pH 7.0
Reconstitution:Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Storage: Store at -20oC
Research Area:Oncology, psoriasis
Background:
S100A7 is 11 kilo-dalton calcium binding protein with 2 EF motifs. It is also called psoriasin due to its significantly elevated level in the skin lesion of psoriasis. The protein is over-expressed in squamous cell tumors of the skin, lung and breast. S100A7 expression is induced after activation of epidermal growth factor receptor.
Application:
IHC (see image): This antibody reacts with breast cancer tissue and thyroid cancer tissue section. The sections were treated by heat induced epitope retrieval before primary antibody (20μg/mL) was added. The secondary antibody was an HRP-labelled goat anti-mouse IgG antibody.
ELISA:This antibody is reactive to recombinant S100A7 protein.
References:
If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.
Additional
Additional Information
Product Specificity | mAb anti-Human S100A7 (psoriasin), 2A3 |
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Application | IHC |
Size | 0.1 mg |
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转运体是介导分子或离子转运跨过生物膜的物质。通常是蛋白质或酶。说得简单一点就是“运输工具”
受体是能与细胞外专一信号分子(配体)结合引起细胞反应的蛋白质。受体与配体结合即发生分子构象变化,从而引起细胞反应,如介导细胞间信号转导、细胞间黏合、细胞胞吞等细胞过程。它起的是“传达员” 的作用
硝酸根从根向地上部茎的长距离运输过程中首先要进行木质部的装载。台湾科学家发现NRT1.5是一个低亲和且依赖于pH的双向转运蛋白,位于质膜并在靠近木质部的中柱鞘细胞中表达,对于硝酸根在木质部的装载具有重要作用。
所以NRT1.5是双向性的转运蛋白
1、被动转运(顺梯度转运):药物依赖于膜两侧的浓度差,从高浓度的一侧向低浓度的一侧扩散转运的过程。大多数药物属于被动转运。
(1)特点:不需要载体,不消耗能量,无饱和现象和竞争性抑制。
(2)影扩散速度的因素:
①膜两侧的药物浓度差。
②药物的理化性质:分子量小、脂溶性大、极性小、非解离型的药物易通过生物膜转运,反之难跨膜转运。
2、主动转运:是一种逆浓度(或电位)差的转运。
特点:需要载体,消耗能量,有饱和现象和竞争性抑制。
微生物吸收营养和排出废弃物都需要通过细胞膜。而细胞膜是磷脂双分子层结构,无论是亲水物质还是疏水物质都无法通过细胞膜。
细胞膜上镶嵌有蛋白质,叫转运蛋白。蛋白质既有疏水基团,又有亲水基团,正是靠蛋白质的这种特殊结构,能够与两类物质结合,并通过蛋白质结构的细微变化,把这两类物质运送到细胞膜的另一侧。
所以,微生物吸收营养物质必须用镶嵌在细胞膜上的转运蛋白来实现。
代谢通路:目前在通路数据库(PATHWAY database) 中代谢通路是建立得最好的,有大约90个参考代谢途径的图形。每个参考代谢途径是一个由酶或EC号组成的网络。