新闻动态
关于我们 - CRB Discovery,Hello Bio/Torin 2/HB2254/50mg
2025-06-29
Product overview
- NameTorin 2
- Short descriptionPotent, selective mTOR inhibitor
- Biological descriptionPotent, selective and ATP-competitive mTOR inhibitor (IC50 = 2.1 nM and EC50 value = 250 pM for inhibition of cellular mTOR activity). Shows 800-fold selectivity over PI3K and >100-fold selectivity over ~400 other protein kinases. Shows potent antiproliferative activity. Causes apoptosis and autophagy and induces G0/G1 cell cycle arrest.
- Biological actionInhibitor
- Purity>98%
- Our products in actionSubmit Your Citation Now
Properties
- Chemical name9-(6-Amino-3-pyridinyl)-1-[3-(trifl uoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H) -one
- Molecular Weight432.4
- Molecular FormulaC24H15F3N4O
- CAS Number1223001-51-1
Storing and Using Your Product
- Storage instructions+4°C
- ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Torin 2
Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.
Simioni et al (2014)Oncotarget 5(20) : 10034-47 PubMedID: 25296981Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.
Liu et al (2013)Cancer Res 73(8) : 2574-86 PubMedID: 23436801Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Liu et al (2011)J Med Chem 54(5) : 1473-80 PubMedID: 21322566
本文链接： https://www.ebiomall.cn/b117-discovery/info-1460790152.html
免责声明 本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容。
版权声明 未经蚂蚁淘授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的，应该授权范围内使用，并注明“来源：蚂蚁淘”。违反上述声明者，本网将追究其相关法律责任。
相关文章
2020-07-05
2020-07-17
2020-07-28
2020-08-06
2020-09-10
2020-09-19
2020-10-12
2020-11-02
2021-03-15
▍
品牌分类
▍
官网分类
