转运档案 - CRB Discovery,LKT/GSK-2606414/G7345/5 mg
- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
GSK-2606414 is an inhibitor of PERK, or eukaryotic initiation factor 2-α kinase 3 (EIK2AK3, also known as protein kinase R-like endoplasmic reticulum kinase). GSK-2606414 exhibits anticancer chemotherapeutic benefit, inhibiting growth of tumor xenografts in animal models.
Product Info
1337531-89-1 |
≥99% |
C24H20F3N5O |
451.44 |
1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone |
White to off white powder |
Shipping and Storage
-20°C |
Ambient |
Downloads
G7345 MSDS PDF |
G7345 Info Sheet PDF |
References
Axten JM, Medina JR, Feng Y, et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207. PMID: 22827572.
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