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Hycult Biotech/MPO, Human, mAb 266-6K1, biotinylated/HM2164BT/50 µg
2025-07-14
Description: MPO, Human, mAb 266-6K1, biotinylated
The monoclonal antibody 266-6K1 recognizes human myeloperoxidase (MPO), an ~135 glycoproteinexpressed in all cells of the myeloid linage. MPO functions as an α2β2 heteromultimer consisting oftwo heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present inazurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used duringphagocytic lysis of engulfed foreign particles which takes part in the defense of the organism throughproduction of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxicintermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO canbe rapidly released and as such useful in body fluids as marker for inflammatory status.Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer,Alzheimers disease, inflammatory bowel disease and multiple sclerosis. Autoimmune antibodies toMPO (so called ANCA) are involved in Wegener’s disease. Since the discovery of MPO deficiency,initially regarded as rare and restricted to patients suffering from severe infections, MPO has attractedmore clinical attention.Specifications:
| HM2164BT |
| Monoclonal antibodies |
| 50 µg |
| 0.5 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin. |
| Biotin |
| Immuno assays, Western blot |
| W: Samples were subjected to SDS-PAGE and transferred to PVDF membrane (Ref.1).IA: The antibody can be used as coat and detector. |
| For Western blotting and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. |
| Mouse IgG1 |
| Human |
| Neutrophils, HL-60 cells |
| 1. La Rocca, G et al; Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure. Basic Res Cardiol 2009, 104: 307 |
| Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year. |
| For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product. |
| Cardiology and metabolism, Pulmonology |
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