Neuromics/Cyckin-C (CCNC)/PR27045-2/2 ug
Type: Protein
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All![\"Picture\"](\"https://www.ebiomall.com/images/neuromics/2017/A8x3a4bx66x1.gif\")
rCCNC (cyclin C) is a member of the cyclin family of proteins. This protein interacts with cyclin-dependent kinase 8 (CDK8) and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this protein peaks in the G1 phase of the cell cycle. It has been shown that a non-cdk8-associated cellular pool of CCNC combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and that this phosphorylation is required for cells to exit GO efficiently. Other results have shown that a marked elevated immunoreactivity of CCNC was found both in neurons and astrocytes in Alzheimers disease (AD). Increased levels of CCNC RNA were detected by ribonuclease protection assay (RPA) in severe AD cases and colocalization of CCNC and its preferred binding partner, CDK8, was only observed in astrocytes but not in neurons. Recombinant CNCC is expressed in E. coli as a full-length protein fused to a proprietary 16-Kd tag (a 6xHis tag is located at the very N-terminal end).Image: CNCC Structure and Sequence.
Applications:
Recombinant human CNCC can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments. The biological activity of this product has not yet been tested.
References:
1. Gene Expressions Specifically Detected in Motor Neurons (Dynactin 1, Early Growth Response 3, Acetyl-CoA Transporter, Death Receptor 5, and Cyclin C) Differentially Correlate to Pathologic Markers in Sporadic Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol 2007 Jul;66(7):617-627.2. Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions. Acta Biol Hung 2007 Mar;58(1):133-7.3. Osmosensitive gene expression of taurine transporter and cyclin C in embryonic fibroblast cells. Adv Exp Med Biol 2006;583:49-57.4. Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. Int J Mol Med 2006 Dec;18(6):1153-8.5. Regulation of the oxidative stress response through Slt2p-dependent destruction of cyclin C in Sacc haromyces cerevisiae. Genetics 2006 Mar;172(3):1477-86.6. [Influence of aerosols on the expression of cyclin B1, cyclin C and proliferating cell nuclear antigen in wound tissue healing of burned rat models] Zhonghua Wai Ke Za Zhi 2005 Oct 1;43(19):1280-3.
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