Adipogen/anti-Cyclin E1, pAb/YIF-LF-PA0168/100 µl
More Information Product Details
Synonyms | CCNE; CCNE1; G1/S-specific Cyclin-E1 |
Product Type | Polyclonal Antibody |
Properties
Immunogen/Antigen | Recombinant human His-Cyclin E1 protein purified from E. coli. |
Application | Western Blot (1:2,000)IHC-P |
Crossreactivity | HumanMouseRat |
Purity Detail | Protein A purified. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Other Product Data | Click here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet. |
Declaration | Manufactured by AbFrontier |
Shipping and Handling
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents
MSDS | No |
Product Specification Sheet
Datasheet ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Cyclins play a key role in the orderly progression of the cell division cycle through their timed expression and their ability to bind, activate and enhance substrate affinity of their associated cyclin-dependent protein kinases (CDKs). E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell cycle until the end of the S-phase. Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the cyclic/Cdk2 complexes initiate a cascade of events that leads to the expression of S-phase specific genes. Besides this specific function as a regulator of S-phase-entry, cyclin E plays a direct role in the initiation of DNA replication, the control of genomic stability, and the centrosome cycle. Essential for the control of the cell cycle at the G1/S (start) transition.Product References1) Moroy T, Geisen C. Int J Biochem Cell Biol. 2004; vol.36: p.1424-39. (General)2) Honda R, et al, EMBO J. 2005; vol.24: p.452-63. (General)Karp G. (2005). Cell and Molecular Biology: Concepts and Experiments, 4th ed, John Wiley and Sons, Hoboken, NJ. (General)
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