Adipogen/anti-Slc7a8 [Lat2], pAb/AG-25T-0120-C100/100 µg
More Information Product Details
Synonyms | Solute Carrier Family 7 Member 8; Lat2; L-type Amino Acid Transporter 2; Large Neutral Amino Acids Transporter Small Subunit 2 |
Product Type | Polyclonal Antibody |
Properties
Source/Host | Rabbit |
Immunogen/Antigen | Synthetic peptide corresponding to a partial sequence of mouse Slc7a8 (Q9QXW9). |
Application | Western Blot: (1:1000; 0.5μg/ml)Immunohistochemistry: (1:250; 2μg/ml) Optimal conditions must be determined individually for each application. |
Crossreactivity | HumanMouse |
Specificity | Recognizes mouse and human Slc7a8. Other species not tested.Detects a ~50kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and other tissues, which is absent in knock-out animals. In some tissues the antibody detects an additional unknown 38kDa band. |
Purity | Antigen affinity purified. |
Formulation | Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. |
Other Product Data | UniProt ID Q9QXW9: Slc7a8 (mouse) |
Shipping and Handling
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Avoid freeze/thaw cycles. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
L-type amino acid transporter (LAT) family members are Na
(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2) are responsible for the majority of cellular leucine uptake. They show increased expression in many cancers and are critical for control of protein translation and cell growth through the mTORC1 pathway. The increased transporter expression observed in cancers is regulated by transcriptional pathways such as hormone receptors, c-myc and nutrient starvation responses.Product References
Neuronal 3,3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome: E.K. Wirth, et al.; J. Neurosci. 29, 9439 (2009)Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8: D. Braun, et al.; Biochem. J. 439, 249 (2011)
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