Adipogen/anti-CARMA1, pAb (AL220)/AG-25B-0004V-C100/100 µg
More Information Product Details
Synonyms | CARD11; Bimp3; Caspase Recruitment Domain-containing Protein 11; CARD-containing MAGUK Protein 1 |
Product Type | Polyclonal Antibody |
Properties
Source/Host | Rabbit |
Immunogen/Antigen | N-terminal human CARMA1 (aa 1-221 containing the CARD domain). |
Application | Immunocytochemistry:(1:200)Immunohistochemistry Western Blot:(1:1000) |
Crossreactivity | HumanMouse |
Specificity | Recognizes human and mouse CARMA1. Detects a band of ~130Dka by Western blot. |
Purity Detail | Protein A-affinity purified. |
Concentration | 1mg/ml |
Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
Other Product Data | This purified antiserum is replacing the product AG-25B-0004 CARMA1 pAb (AL220) (neat antiserum) with same specifications. |
Shipping and Handling
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Avoid freeze/thaw cycles. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
CARMA1 is involved in the costimulatory signal essential for T cell receptor (TCR)-mediated T cell activation. Its binding to DPP4 induces T cell proliferation and NF-κB activation in a T cell receptor/CD3-dependent manner. CARMA1 activates NF-κB via Bcl10 and IKK.Product References
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappaB activation: O. Gaide, et al.; Nat. Immunol. 3, 836 (2002)MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-κB-dependent proliferative advantage and resistance against FAS-induced cell death in B cells: L. Ho, et al.; Blood 105, 2891 (2005)Phosphorylation of the CARMA1 Linker Controls NF-κB Activation: K. Sommer, et al.; Immunity 23, 561 (2005)Overexpression of Caspase Recruitment Domain (CARD) Membrane-Associated Guanylate Kinase 1 (CARMA1) and CARD9 in Primary Gastric B-Cell Lymphoma: S. Nakamura, et al.; Cancer 104, 1885 (2005)Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1: R.B. Medeiros, et al.; Science 316, 754 (2007)Bcl10 Controls TCR- and FcγR-Induced Actin Polymerization: D. Rueda, et al.; J. Immunol. 178, 4373 (2007)The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008)MAGUK-Controlled Ubiquitination of CARMA1 Modulates Lymphocyte NF-κB Activity: M.E. Moreno-Garcia, et al.; Mol. Cell Biol. 30, 922 (2010)Interaction of calmodulin with Bcl10 modulates NF-κB activation: S. Edin, et al.; Mol. Immunol. 47, 2057 (2010)
本文链接： https://www.ebiomall.cn/b285-adi/info-1525184382.html
免责声明 本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容。
版权声明 未经蚂蚁淘授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的，应该授权范围内使用，并注明“来源：蚂蚁淘”。违反上述声明者，本网将追究其相关法律责任。
