Adipogen/EM574/AG-CN2-0102-C250/250 µg
More Information Product Details
Synonyms | Motilide; Idremcinal; 8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin |
Product Type | Chemical |
Properties
Formula | C39H69NO12 |
MW | 744.0 |
CAS | 110480-13-2 |
Source/Host Chemicals | Semisynthetic from erythromycin A. |
Purity Chemicals | ≥95% (HPLC) |
Appearance | White to off-white powder. |
Solubility | Soluble in methanol, ethanol, DMSO, chloroform, acetone, ethyl acetate or acetonitrile. Insoluble in water or hexane. |
Declaration | Synthesized by the Organic Chemistry Group of The Kitasato Institute. |
InChi Key | FPBKIOZMKHHNLL-FMUXYZBNSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Shows strong gastrointestinal motor stimulating (GMS) activity [1, 2, 5].
- Motilin receptor agonist [3, 6].
- Stimulates smooth muscle cell contraction [3].
- Stimulates cholinergic neurons in a non-vagal pathway [4].
- Enhances gastrointestinal contractile activity and accelerates gastric emptying [7, 8].
- Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor) [9].
Product References
Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship: S. Omura, et al.; J. Antibiot. (Tokyo) 38, 1631 (1985)Macrolides with gastrointestinal motor stimulating activity: S. Omura, et al.; J. Med. Chem. 30, 1941 (1987)EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M. Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994)Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs: N. Inatomi, et al.; Jpn. J. Pharmacol. 71, 29 (1996)Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. (Tokyo) 49, 794 (1996)EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit: F. Sato, et al.; Eur. J. Pharmacol. 322, 63 (1997)Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs: T. Tanaka, et al.; J. Pharmacol. Exp. Ther. 287, 712 (1998)Effect of EM574 on postprandial pancreaticobiliary secretion, gastric motor activity, and emptying in conscious dogs: T. Tanaka, et al.; Dig. Dis. Sci. 44, 1100 (1999)EM574, a motilide, has an orexigenic activity with affinity for growth-hormone secretagogue receptor: A. Asakawa, et al.; J. Gastroenterol. Hepatol. 18, 881 (2003)
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