Adipogen/Chetomin/BVT-0161-M001/1 mg
More Information Product Details
Synonyms | CTM; Chaetomin; NSC289491; BRN0077366 |
Product Type | Chemical |
Properties
Formula | C31H30N6O6S4 |
MW | 710.9 |
CAS | 1403-36-7 |
Source/Host Chemicals | Isolated from Chaetomium sp. |
Purity Chemicals | ≥98% (HPLC) |
Appearance | Off-white to fawn solid. |
Solubility | Soluble in DMSO, ethyl acetate or pyridine; fairly soluble in methanol or 100% ethanol; insoluble in water. |
Identity | Determined by 1H-NMR. |
Declaration | Manufactured by BioViotica. |
InChi Key | ZRZWBWPDBOVIGQ-OKMJTBRXSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from moisture.Protect from light when in solution. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C.After reconstitution protect from light at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Antibiotic.
- Inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1α and HIF-2α.
- Histone H3K9 methyltransferases G9a and Suv39h inhibitor.
- Tumor growth inhibitor.
- Angiogenesis inhibitor.
- Potent immunosuppressor.
- Antibacterial and antifungal.
- Strong inducer of retinal pigment epithelium (RPE).
Product References
The structure of chetomin: A.G. McInnes, et al.; JACS 98, 6741 (1976)Effects of chetomin on growth and acidic fermentation products of rumen bacteria: W.C. Jen and G.A. Jones; Can. J. Microbiol. 29, 1399 (1983)Immunomodulatory constituents from an Ascomycete, Chaetomiumseminudum: H. Fujimoto, et al.; J. Nat. Prod. 67, 98 (2004)Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway: A.L. Kung, et al.; Cancer Cell 6, 33 (2004)Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells: A. Staab, et al.; BMC Cancer 7, 213 (2007)Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1α (HIF-1α) and p300 by a zinc ejection mechanism: K.M. Cook, et al.; J. Biol. Chem. 284, 26831 (2009)Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine: K. M. Wang, et al.; JACS 131, 18078 (2009)Up-regulation of pro-inflammatory genes as adaptation to hypoxia in MCF-7 cells and in human mammary invasive carcinoma microenvironment: M. Tafani, et al.; Cancer Sci. 101, 1014 (2010)Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines: M. Takahashi, et al., J. Antibiot. 65, 263 (2012)Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer: K.M. Reece, et al.; Mol. Cancer 13,91 (2014)Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells: J. Maruotti, et al.; PNAS 112, 10950 (2015)
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