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Zyagen/IL-5 Recombinant Protein/7944/1 Ea

  
  2025-10-03
  

Background

IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant human IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.

Specifications

Additional Names
EDF, BCDFII, TRF
Preparation
The ED50was determined by the dose - dependent proliferation of TF - 1 cells was ? 0.15 ng/ml, corresponding to a specific activity of ? 6.6 x 106units/mg.
Location
MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES
Source
E. coli
Reactivity
n/a
Tested Application
n/a
Storage
The lyophilized IL-5 recombinant protein is stable for at least 2 years from date of receipt at -20ËšC. Reconstituted IL-5 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20ËšC. As with any protein, exposing IL-5 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Species Reactivity
n/a
Purity
Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).

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