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Enzolifesciences/Neurofilament M monoclonal antibody (3H11)/ADI-NBA-140-E/100µl
2026-08-24
Product Specification:
| Alternative Name: | NEFM, NF-M |
| Clone: | 3H11 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant rat neurofilament M (NF-M) (C-terminal fragment). |
| UniProt ID: | P12839 |
| Species reactivity: | Human, Mouse, RatChicken |
| Applications: | ICC, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (1:25-1:100)Western Blot (1:200-1:1,000 ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol, 0.01% thimerosal, and 1.0mg/ml BSA. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Neuron-specific neurofilaments belong to the intermediate filament protein family, also known as 10nm filaments. As major constituents of the axonal cytoskeleton, neurofilaments contain heteropolymers of three major proteins: 200 kDa heavy molecular weight protein NF-H, 160 kDa medium molecular weight protein NF-M, and 68 kDa light molecular weight protein NF-L, with the ratio of each changing during neuronal development. All three proteins contain globular head and tail domains flanking a central alpha-helical domain. An accumulation of neurofilament proteins and/or mutations in one of the three major proteins occur during the progression of numerous neurological diseases, including ALS. |
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