ACS Appl. Mater. InterfacesAll Publications/WebsiteOR SEARCH CITATIONS Recently ViewedYou have not visited any articles yet, Please visit some articles to see contents here. RETURN TO ISSUEPREVResearch ArticleNEXTHighly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal NanoprobesXiangwei LinXiangwei LinPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaMeasurement and Control Research Center, Department of Control Science and Engineering, Harbin Institute of Technology, Harbin 150001, ChinaMore by Xiangwei Lin,Chengbo LiuChengbo LiuResearch Laboratory for Biomedical Optics and Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaMore by Chengbo Liu,Zonghai ShengZonghai ShengPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaMore by Zonghai Sheng,Xiaojing GongXiaojing GongResearch Laboratory for Biomedical Optics and Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaMore by Xiaojing Gong,Liang SongLiang SongResearch Laboratory for Biomedical Optics and Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaMore by Liang Song,Ruifang ZhangRuifang ZhangDepartment of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, ChinaMore by Ruifang Zhang,Hairong Zheng*Hairong ZhengPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China*E-mail: [email protected] (H.Z.).More by Hairong Zheng,andMingjian Sun*Mingjian SunMeasurement and Control Research Center, Department of Control Science and Engineering, Harbin Institute of Technology, Harbin 150001, China*E-mail: [email protected] (M.S.).More by Mingjian Sunhttp://orcid.org/0000-0001-8719-524XCite this: ACS Appl. Mater. Interfaces 2018, 10, 31, 26064–26074Publication Date (Web):July 25, 2018Publication History Received2 June 2018Accepted16 July 2018Published online25 July 2018Published inissue 8 August 2018https://doi.org/10.1021/acsami.8b09142Copyright © 2018 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views935Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.Get e-AlertsAbstractThe biomedical imaging of metastatic breast cancer, especially in lymphatic and lung metastasis, is highly significant in cancer staging as it helps assess disease prognosis and treatment. Using an albumin-indocyanine green dual-modal nanoprobe developed in our laboratory, in vivo fluorescence imaging and photoacoustic imaging of metastatic breast cancer tumors were performed separately. Fluorescence imaging at the near-infrared window features high imaging sensitivity but is generally limited by a low imaging depth. Thus, tumors can only be observed in situ whereas tumor cells in the lymph nodes and lung cannot be imaged in a precise manner. In contrast, photoacoustic imaging often helps overcome the limitations of imaging depth with high acoustic spatial resolution, which could provide complementary information for imaging cancer metastases. Ex vivo fluorescence and photoacoustic imaging were also performed to verify the tumor metastatic route. This study may not only provide insights into the design of dual-modal nanoprobes for breast cancer diagnosis but may also demonstrate the superiority of combined fluorescence imaging and photoacoustic imaging for guiding, monitoring, and evaluating lymphatic and lung metastatic stages of breast cancer with a high imaging specificity as well as sensitivity.KEYWORDS:breast cancer metastasis indocyanine green dual-modal nanoprobes fluorescence imaging photoacoustic imagingSupporting InformationARTICLE SECTIONSJump ToThe Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.8b09142.Schematic illustration of acoustic resolution photoacoustic microscopy; results of H E staining images of primary tumor, lymphatic, and lung metastasis in breast cancer, cytotoxicity of HSA-ICG NPs against 4T1 cells; photograph and fluorescence images of collected urine and droppings of mice 24 h post injection of HSA-ICG NPs (PDF)am8b09142_si_001.pdf (508.09 kb) Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html. Cited ByThis article is cited by 8 publications.Junfei Han, Lu Zhang, Mingyue Cui, Yuanyuan Su, Yao He. Rapid and Accurate Detection of Lymph Node Metastases Enabled through Fluorescent Silicon Nanoparticles-Based Exosome Probes. Analytical Chemistry 2021, 93 (29) , 10122-10131. https://doi.org/10.1021/acs.analchem.1c01010Yanshu Wang, Liping Jiang, Yuwen Zhang, Yimei Lu, Jinning Li, He Wang, Defan Yao, Dengbin Wang. Fibronectin-Targeting and Cathepsin B-Activatable Theranostic Nanoprobe for MR/Fluorescence Imaging and Enhanced Photodynamic Therapy for Triple Negative Breast Cancer. ACS Applied Materials Interfaces 2020, 12 (30) , 33564-33574. https://doi.org/10.1021/acsami.0c10397Wujun Xu, Jarkko Leskinen, Jenni Tick, Emilia Happonen, Tanja Tarvainen, Vesa-Pekka Lehto. Black Mesoporous Silicon as a Contrast Agent for LED-Based 3D Photoacoustic Tomography. ACS Applied Materials Interfaces 2020, 12 , 5456-5461. https://doi.org/10.1021/acsami.9b18844Xiaolu Zhang, Meng Zhao, Ling Wen, Manran Wu, Yi Yang, Yujuan Zhang, Yan Wu, Jian Zhong, Haibin Shi, Jianfeng Zeng, Guanglin Wang, Mingyuan Gao. Sequential SPECT and NIR-II imaging of tumor and sentinel lymph node metastasis for diagnosis and image-guided surgery. Biomaterials Science 2021, 9 , 3069-3075. https://doi.org/10.1039/D1BM00088HZun Wang, Min Chen, Jing-Jing Liu, Rong-He Chen, Qian Yu, Gui-Mei Wang, Li-Ming Nie, Wen-He Huang, Guo-Jun Zhang. Human Serum Albumin Decorated Indocyanine Green Improves Fluorescence-Guided Resection of Residual Lesions of Breast Cancer in Mice. Frontiers in Oncology 2021, 11 https://doi.org/10.3389/fonc.2021.614050Huang Wen, Konstantin Tamarov, Emilia Happonen, Vesa‐Pekka Lehto, Wujun Xu. Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics. Advanced Therapeutics 2021, 4 , 2000207. https://doi.org/10.1002/adtp.202000207Lizbeth Anahí Serrano-Aguilar, Rosa María Quispe-Siccha, Argelia Pérez-Pacheco, Roberto Mosiñoz-Montes, Gregorio Quintero-Beuló, Azcary Vázquez-Tinajero, Fernando Lara-González, Mercedes Hernández-González, Joselín Hernández-Ruíz, Juan C. López-Alvarenga. Photothermal Signature Characterization of Breast Microcalcifications Ex-Vivo by Photoacoustic Method. 2020,,, 1261-1272. https://doi.org/10.1007/978-3-030-30648-9_163Hao Liu, Rebecca T. Marquez, Xiaoqing Wu, Ke Li, Shweta Vadlamani, Song Li, Ya Wang, Liang Xu, Daocheng Wu. A non-intrusive evaluation method for tumor-targeting characteristics of nanomedicines based on in vivo near-infrared fluorescence imaging. Journal of Materials Chemistry B 2019, 7 (31) , 4751-4757. https://doi.org/10.1039/C9TB00882AExport articles to MendeleyGet article recommendations from ACS based on references in your Mendeley library.Export articles to MendeleyGet article recommendations from ACS based on references in your Mendeley library. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Please login with your ACS ID before connecting to your Mendeley account.Login with ACS ID This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy. CONTINUE