MOG3555-P-5    Rat/Mouse Myelin Oligodendrocyte Glycoprotein 35-55 aa peptide pure 公司介绍：美国Genemed Synthesis Inc公司，于1994年成立于旧金山，是美国知名的生命科学实验室试剂产品生产厂家，主要产品为抗体，多肽，试剂盒，蛋白质和DNA合成服务等，由于公司发展需要，2007年搬迁到圣安东尼奥市，公司进入了快速全面的发展阶段，产品已经服务于世界各地。产    品：Rat/Mouse Myelin-oligodendrocyte glycoprotein (MOG) 35-55 PeptidesMyelin-oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) superfamily, exclusively expressed in the central nervous system (CNS). MOG is an intrinsic membrane protein characterized by a N-terminal extracellular immunoglobulin-like variable (Ig-like V-type) domain, two hydrophobic transmembranedomains and a cytoplasmic C-terminal region. The N-terminal MOG domain has strong homology with the N-terminus of butyrophilin, a protein expressed in the lactating mammary gland. Human MOG gene is localized to chromosome 6p22-p21.3 (band C of mouse chromosome 17) at the distal end of the MHC class Ib region. Despitethe similar names, oligodendrocyte-myelin glycoprotein (OMG) is a separate protein encoded within a large intron of the NF1 gene. The 2 glycoproteins are associated specifically with oligodendrocytes and myelin, but have quite different roles in myelinogenesis and are structurally unrelated. MOG is an intrinsic membrane molecule with 2 transmembrane domains, whereas OMG is anchored in the outer leaflet of the plasma membrane through a glycophospholipid tail. OMG belongs to the family of proteins with a series of tandem leucine-richrepeats, while MOG is a member of the Ig superfamily.MOG contains nine exons and eight separating introns, giving rise to at least eight alternatively spliced variants encoding for the MOG-alpha1-4 and MOG-beta 1-4 isoforms (16-26 kDa). The different MOG isoforms may interact to form homo- and heterodimers and trimers (55 and 78 kDa). During the last step of myelinogenesis, MOG is expressed in the CNS on the outermost surface (external lamella) of mature myelin sheaths and on the cell surface of myelinating oligodendrocytes. MOG has a variety of functions including a role as a cellular adhesion molecule. It may be involved also in the completion and/or maintenance of the myelin sheath and in cell-cell communication. MOG is also thought to function as a regulator of oligodendrocyte microtubule stability and as a mediator of interactions between myelin and the immune system in the complement cascade. Although MOG is a relatively minor component of the myelin membrane, it is a primary autoantigen target involved in the pathogenesis of immune-mediated demyelinating diseases including experimental autoimmuneencephalomyelitis (EAE) and multiple sclerosis. The MOG 35-55 peptide is an immunodominant epitope of MOGthat induces strong T and B cell responses. A single injection of this peptide fragment can produce an exacerbating-remitting neurologic disease with extensive plaque-like demyelination, which may serve as a model for investigating multiple sclerosis. SpecificityRat and mouse MOG35-55 peptide is 100% conserved common marmoset, 95% in chimp, bovine, Pongo pygmaeus (Orangutan),pig, and human MOG. MOG35-55 sequence is found in MOG isoforms alpha-1, alpha-2, beta-2, beta-3, beta-4, and isoforms 9.This product is for In vitro research use only. Human MOG Isoforms, CommentsAccession #Sources of PeptidesCat # MOG3555-P-5Sequence: MEVGWYRSPFSRVVHLYRNGKMol Wt: 2582Formula: C118H177N35O29SForm: Powder Solubility: Water (1 mg/ml)Storage: Store powder at -20oC for up to 6 months.After reconstitution in water, store solution in small aliquots at -20oC for 3-6 months. Do not freeze and thaw or store diluted solutions.General References（文献）: Pham-Dinh, D (1995) Genomics 29: 345-352; Pham-Dinh, D. (1995) Immunogenetics 42: 386-391; Pham-Dinh, D (1993) PNAS 90: 7990-7994; Roth, M.-P (1995) Genomics 28: 241-250; Ichikawa M (1996) J. Immunol. 157, 919-926;Bernard CC (1997) J. Mol. Med. 75, 77-87; Slavin A (1998) A utoimmunity 28, 109-120Antibodies to MOG35-55, and MOG autoantibodies detection kit MOG3555-P-5 70318A

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