salimetrics/Chromogranin A/chromogranin-a/25 μL
| Serum-Saliva Correlation | NA |
| Sensitivity | 7 ng/mL |
| Sample Test Volume | 25 μL |
| Recommended Collection Volume | 75 μL* |
| Special Considerations | No |
| Collection Protocol | Download PDF |
ChromograninA (CgA, also known as parathyroid secretory protein 1) is an acidic secretory protein belonging to the granin family, found in many types of neuroendocrine tissues. It is stored in secretory vesicles with other types of neurotransmitters and peptide hormones. Granins play an important role in the sorting and aggregation of secretory products in the trans-golgi network, and in the subsequent formation of secretory granules. (1,2,3,4,5) CgA is co-secreted from sympathetic nerves along with the catecholamines, and it has been shown to be useful as a biomarker of sympathetic nervous activity. CgA production has been found in human submandibular saliva glands, and CgA can be measured in saliva. The correlation between saliva and serum CgA is not well understood. (5,6,7) A circadian rhythm for CgA in normal subjects has been reported, with peak values during the night around 11:00 and a nadir in the morning around 8:00. (8)
Feldman, S.A., Eiden, L.E. (2003). The chromogranins: Their roles in secretion from neuroendocrine cells and as markers for neuroendocrine neoplasia. Endocr Pathol, 14(1), 3-23.O,Connor, D.T., Frigon, R.P., Sokoloff, R.L. (1984). Human chromogranin A. Purification and characterization from catecholamine storage vesicles of human pheochromocytoma. Hypertension, 6, 2-12.(Ozawa, H., Takata, K. (1995). The granin family -- Its role in sorting and secretory granule formation. Cell Struct Funct, 20, 415-20.)Montero-Hadjadje, M., Vaingankar, S., Elias, S., et al. (2008). Chromogranins A and B and secretogranin II: Evolutionary and functional aspects. Acta Physiol (Oxf), 192(2), 309-24.Helle, K.B. (2010). Chromogranins A and B and secretogranin II as prohormones for regulatory peptides from the diffuse neuroendocrine system. Results Probl Cell Differ, 50, 21-44.Koh, D.S.-Q., Koh, G. C.-H. (2007). The use of salivary biomarkers in occupational and environmental medicine. Occup Environ Med, 64, 202-10.Kanno, T. (2004). Compound exocytosis of secretory granules containing salivary chromogranin A in granular duct cells in rat submandibular gland: The last study in collaboration with the late professor Noboru Yanaihara at Yanaihara Institute. Reg Peptides, 123, 3-7.Giampaolo, B. Angelica, M., Antonio, S. (2002). Chromogranin A in normal subjects, essential hypertensives and adrenalectomized patients. Clin Endocrinol (Oxf), 57, 41-50.
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