美国的Nanoprobes公司（http://www.nanoprobes.com/）应用金标记和先进的控制方式和位置，非常适合纳米生物技术和纳米结构材料。

EnzMet™

EnzMet™ (Enzyme Metallography) is a new biological labeling and staining method developed at Nanoprobes, which uses a targeted enzymatic probe with a novel metallographic substrate to provide a quantum leap in staining clarity over conventional chromogenic and fluorescent substrates for immunohistochemistry (IHC) and in situ hybridization (ISH) applications. It has proven highly sensitive both for ISH, where it readily visualizes endogenous copies of single genes, and immunohistochemistry (IHC) detection. It has also been used as an electrical detection method for biochips.

GoldiBlot™

Goldiblot™ His Detection Kit is a rapid, sensitive alternative to enzymatic methods for thedetection of recombinant His-tagged proteins on membrane blots such as immunoblots and westerns. It uses nitrilotriacetic acid (NTA)-nickel (II)-functionalized gold nanoparticles, which bind tightly and selectively to His tags, followed by metal enhancement for direct visualization.