Bpsbioscience/Tenovin-1/27660-2/50 mg-蚂蚁淘商城

新闻动态

Bpsbioscience/Tenovin-1/27660-2/50 mg

2024-04-29

MW: 369.5 Da CAS Registry #: 380315-80-0 Formula: C₂₀H₂₃N₃O₂S Target: SIRT1, SIRT2 Background:Tenovin-1, a small molecule discovered by a cell-based screen, is a bio-active activator of p53 that elevates the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis. Tenovin-1 also exerts inhibition against human sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2), two important members of the sirtuin family. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. An improved and water-soluble version of tenovin-1 has been found to decrease the peptide deacetylase activity of human SIRT1 and SIRT2 with IC50 values of 21 µM and 10 µM respectively. Description:Tenovin-1 inhibits the protein-deacetylating activities of SIRT1 and SIRT2. Tenovin-1 is also a p53 activator and elevates the amount of p53 protein within 2 hr of treatment, without altering p53 mRNA levels. Tenovin-1 protects against MDM2-mediated p53 degradation via ubiquitination. Synonym(s): N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide Purity:

≥99% by HPLC

Solubility: Soluble in DMSO 74 mg/ml (200 mM), or 15% Captisol (modified cyclodextrin) 15 mg/ml. Solubility in water or ethanol is < 1 mg/ml (< 1 mM) Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): Lain S, et al. Cancer Cell. 2008 May;13(5):454-63. Scientific Category: Deacetylase Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.

本文链接： https://www.ebiomall.cn/b579-activebio/info-1563422328.html

免责声明本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容。

没有了

www.biomart.cn/infosupply/60188431.htm

2024-01-14

设备和仪器档案 - 第 7 页，共 8 页 - www.bio-active.co.th

2024-01-12

...合作品牌 - 上海睿铂赛生物科技有限公司ShangHai Rebiosci...

2024-01-25

Adipogen/AT7519 hydrochloride/SYN-1010-M050/50 mg

2024-01-17

Bpsbioscience/Tenovin-1/27660-2/50 mg