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Bachem/WRW4 trifluoroacetate salt/H-7596.0001/1 mg
2025-05-10
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Antagonist of formyl peptide receptor-like 1 (FPRL1) signalling. WRW4 inhibits WKYMVm binding to FPRL1 (IC₅₀ 0.23 mM) as well as the intracellular calcium release induced by WKYMVm, MMK-1, amyloid β42, and F peptide. The tryptophan-rich peptide also inhibits FPRL1-mediated signalling in human neutrophils and blocks chemotactic migration and superoxide generation by Aβ42. WRW4 inhibited the activation of FPRL2 by F2L (H-6294), an FPRL2-selective endogenous agonist, resulting in the complete inhibition of intracellular calcium increase and chemotactic migration. Item Number4095537APC Number15-1-16One Letter CodeWRWWWW-NH₂Molecular FormulaC₆₁H₆₅N₁₅O₆Relative Molecular Mass1104.27CAS Registry Number[878557-55-2] netSourceSyntheticStorage Conditions-20 ± 5 °CAreas of Interest Alzheimers Disease Links / Documents:- Peptide Calculator
- MSDS
Product citations
M.R.White et al., PLoS ONE, 9, e101364 (2014) N.He et al., Cell Death Dis., 4, e924 (2013) A.Slowik et al., Mol. Neurodegener., 7, 55 (2012) L.-O.Brandenburg et al., J. Neurochem., 113, 749 (2010) E.H.Shin et al., Biochem. Biophys. Res. Commun., 341, 1317 (2006) Y.S.Bae et al., J. Immunol., 173, 607 (2004)本文链接： https://www.ebiomall.cn/b66-bachem/info-1528440014.html
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