Agrin in Postsynaptic Differentiation-蚂蚁淘商城

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Agrin in Postsynaptic Differentiation

2025-06-21

Theheparansulphateproteoglycanagriniswellknownasthekeyassemblyfactorofpostsynapticdifferentiationattheneuromuscularjunction(NMJ),butrecentdatasuggestitalsoplaysadirectroleintheorganizationoftheCytoskeletonintheskeletalmuscle.Signalingthroughmuscle-specificproteinssuchasmusclespecifickinase(MuSK)andoracetylcholinereceptor(AchRs)/rapsyn,agrincanactivateubiquitouslyexpressedRac,Cdc42,andp21-activatedkinase(PAK)thatareinvolvedinactinpolymerization.Agrinalsoengagessignalingpathwaysofseveralpotentoncogenes(i.e.,SFK,ErbBreceptors,andcortactin).

Contributor:KosiGramatikoff,PhD

REFERENCES:BezakovaG,RueggMA.Newinsightsintotherolesofagrin.NatRevMolCellBiol.2003Apr;4(4):295-308.MollJetal.Anagrinminigenerescuesdystrophicsymptomsinamousemodelforcongenitalmusculardystrophy.Nature.2001Sep20;413(6853):302-7.

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