LKT/OLIGOMYCIN/O4533/10 mg
- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
This product consists of a mixture of oligomycins A, B and C. Oligomycins are macrolide antibiotics that exhibit antibacterial activity. Oligomycins suppress oxidative phosphorylation in the mitochondria by inhibiting K+-activated current of the Na+/K+ ATPase. In vitro, oligomycins inhibit IFN-γ- and TNF-α-induced reductions in transepithelial resistance and paracellular permeability. Oligomycins also inhibit the increase in expression and phosphorylation of MLC, preventing intestinal epithelial barrier dysfunction induced by inflammatory cytokines.
Product Info
1404-19-9 |
≥97% |
(5Z,7E,21E)-4-ethyl-11,12,15,19-tetrahydroxy-6-(2-hydroxypropyl)-5,10,12,14,16,18,20,26,29-nonamethylspiro[24,28-dioxabicyclo[23.3.1]nonacosa-5,7,21-triene-27,2-oxane]-13,17,23-trione |
Oligomycin complex |
84-100°C |
Soluble in ethanol, DMSO, acetone. |
White to off white powder |
Shipping and Storage
4°C |
Ambient |
Downloads
O4533 MSDS PDF |
O4533 Info Sheet PDF |
References
Liu H, Wang P, Cao M, et al. Protective role of oligomycin against intestinal epithelial barrier dysfunction caused by IFN-γ and TNF-α. Cell Physiol Biochem. 2012;29(5-6):799-808. PMID: 22613980.
Ding Y, Hao J, Rakowski RF. Effects of oligomycin on transient currents carried by Na+ translocation of Bufo Na+/K(+)-ATPase expressed in Xenopus oocytes. J Membr Biol. 2011 Oct;243(1-3):35-46. PMID: 21877177.
Bittar EE. Effect of inhibitors and uncouplers on the Na pump of the Maia muscle fibre. J Physiol. 1966 Nov;187(1):81-103. PMID: 5972170.
CHAPPELL JB, CROFTS AR. THE EFFECT OF ATRACTYLATE AND OLIGOMYCIN ON THE BEHAVIOUR OF MITOCHONDRIA TOWARDS ADENINE NUCLEOTIDES. Biochem J. 1965 Jun;95:707-16. PMID: 14342506.
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