Enzolifesciences/Vasopressin receptor V<sub>1b</sub> polyclonal antibody/ADI-905-750-100/100µg-蚂蚁淘商城

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Enzolifesciences/Vasopressin receptor V_1b polyclonal antibody/ADI-905-750-100/100µg

2025-05-11

Product Specification:

Alternative Name:	AVPR1B

Host:	Rabbit

Immunogen:	Synthetic peptide corresponding to the sequence near the N-terminus of rat vasopressin receptor V_1b.

UniProt ID:	P48974

Species reactivity:	Human, Mouse, Rat

Applications:	ELISA, IHC, WB

Application Notes:	Suitable for cell-based and membrane-based ELISA.Predicted MW of ~47kDa. Higher MW species (~50kDa) also observed by Western blot which reflects post-translational modification of the receptor.

Purity Detail:	Peptide affinity purified.

Formulation:	Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.

Handling:	Keep on ice at all times.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1), V1b (V3), and V2. V1b receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas. V2 receptors in the collecting ducts of the kidneys stimulate adenylyl cyclase activity, regulating the reabsorption of water via aquaporin channels.

Manufacturer:	Manufactured by Proteimax.