
The inducible costimulator CD278 (ICOS) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Secondary signaling through CD28 or CD278 results in discrete cytokine secretion profiles by the activated T cells.1 Signaling by either molecule is effectively down regulated by CD152 (CTLA-4) engagement.2 Human CD275 (ICOSL, GL50, B7-H2) is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be the ligand for CD278 (ICOS).3 Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain. 4
Isotype: Murine IgG1 Kappa
Immunogen: Human HPB-MLT cells, recombinant human CD278(ICOS)-muIg
Specificity: Antibody ANC6C6 binds to recombinant and cell surface CD278(ICOS)
Functional Application: Antibody ANC6C6 blocks binding of Recombinant CD275-muIg to CD278. It blocks CD28-superagonist/CD275(LICOS) mediated T cell proliferation in vitro(7).
References:
1) Beier, K.C., R.A. Kroczek, et al. 2000, Eur J Immunol. 30(12):3707-3717.
2) Riley, J.L., C.H. June, et al. 2001, J. Immunol. 166: 4943-4948.
3) Ling, V., M. Collins, et al. 2000, J. Immunol. 164: 1653-1657.
4) Ling, V., M. Collins, et al. 2001, J. Immunol. 166: 7300-7308.
5) Tomoki Ito, Yong-Jun Liu, et al. (2008) Immunity 28: 870-880.
6) Hyung W Lim, Chang H Kim. (2007) J Immunol 179: 7448-7456.
7) S Weissmuller, Z Waibler, et al. (2012) Blood 119(26):6268-6277.
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适应症下会标注“本品适用于敏感菌所致......”字样;
药理作用下会标注“本品属......类抗菌素”字样。
2.β-内酰胺类青霉素(阿莫西林、氨苄西林、羧苄西林) 头孢菌素、碳青霉烯类、头霉素、单内酰环类、β-内酰酶抑制剂、甲氧青霉素类
3.大环内酯类 红霉素、白霉素(吉他霉素)、罗红霉素、阿奇霉素、克拉霉素、乙酰螺旋霉素、麦迪霉素、交沙霉素等
4 酰胺醇类:包括氯霉素、甲砜霉素等
5 四环素类:包括四环素、土霉素(强力霉素)、金霉素等
6 林可酰胺类 克林霉素、林可霉素
7.糖肽类抗生素: 比如万古霉素、替考拉宁
8 抗真菌抗生素:如灰黄霉素、两性霉素B
9 抗肿瘤抗生素:如丝裂霉素、放线菌素D、博莱霉素、阿霉素等
10 具有免疫抑制作用的抗生素如环孢霉素
11 多磷类抗生素:如磷霉素

