
Glucocorticoid induced Tumor Necrosis Factor receptor family related gene (GITR, AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18. GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break T cell suppression (2). GITR has been implicated as a regulatory mechanism in anti-parasitic immune resposes (4), and is involved with Macrophages activation in atherosclerotic plaque formation (3).
Clone ANC7D6-1E7 binds to human GITR in EIA and on stimulated cell surface in FACS. Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.
Isotype: Murine IgM kappa
Immunogen: Recombinant human GITR, PHA stimulated human PBL
Specificity: Antibody ANC7D6-1E7 binds to human GITR in EIA and on cell surface in FACS. Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.
References:
1) Gurney AL, et al. (1999) Curr Biol 9(4): 215-218.
2) Ji HB, et al. (2004 ) J Immunol 172(10): 5823-5827.
3) Kim WJ, WH Lee, et al. (2006) Immunology 119(3): 44-9.
4) Furze RC, Selkirk ME, et al. (2006) Microbes Infect 8 (12-13): 2803-10.
5) Kohm AP, SD Miller, et al. (2004) J Immunol 172: 4686-4690. .
6) McHugh, R.S. et al. (2002) Immunity 16:311.
7) Shin, H.H. et al. (2002) FEBS Lett. 514:275.
8). Shimizu, J. et al. (2002) Nature Immunol. 3:135.
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适应症下会标注“本品适用于敏感菌所致......”字样;
药理作用下会标注“本品属......类抗菌素”字样。
2.β-内酰胺类青霉素(阿莫西林、氨苄西林、羧苄西林) 头孢菌素、碳青霉烯类、头霉素、单内酰环类、β-内酰酶抑制剂、甲氧青霉素类
3.大环内酯类 红霉素、白霉素(吉他霉素)、罗红霉素、阿奇霉素、克拉霉素、乙酰螺旋霉素、麦迪霉素、交沙霉素等
4 酰胺醇类:包括氯霉素、甲砜霉素等
5 四环素类:包括四环素、土霉素(强力霉素)、金霉素等
6 林可酰胺类 克林霉素、林可霉素
7.糖肽类抗生素: 比如万古霉素、替考拉宁
8 抗真菌抗生素:如灰黄霉素、两性霉素B
9 抗肿瘤抗生素:如丝裂霉素、放线菌素D、博莱霉素、阿霉素等
10 具有免疫抑制作用的抗生素如环孢霉素
11 多磷类抗生素:如磷霉素

