
The human CD1 genetic locus consists of five closely related genes (2). Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells (3). CD1 molecules have a specialized lipid antigen-presenting function (4,5) and it is unlikely that they present conventional peptide antigens. CD1 may also be involved in costimulation (6).
Isotype: Murine IgG1 kappa
Immunogen: Human T cell line Molt 4
Specificity: Antibody M241 is specific for the CD1c molecule of about 48 kd (1,2, 7).
References:
1. R.W. Knowles and W. F. Bodmer (1982) Eur J Immunol 12: 676-681.
2. Leukocyte Typing III (A.J. McMichael, et al, eds.) Oxford University Press, Oxford, (1987) p. 882.
3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 337-341.
4. E.M. Beckman, et al, (1994) Nature 372: 691-694.
5. R.S. Blumberg, et al, (1995) Immunol Rev 147: 5-29.
6. S.M. Behar, et al, (1995) J Exp Med 182: 2007-2018.
7. L H Martin, C Milstein, et al. (1987) PNAS 84: 9189-9193.
8. A -C R Beitnes, F L Jahnsen, et al (2011) Sandinavian J Immunol 74(2): 186-194. PMID: 21392045
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>
适应症下会标注“本品适用于敏感菌所致......”字样;
药理作用下会标注“本品属......类抗菌素”字样。
2.β-内酰胺类青霉素(阿莫西林、氨苄西林、羧苄西林) 头孢菌素、碳青霉烯类、头霉素、单内酰环类、β-内酰酶抑制剂、甲氧青霉素类
3.大环内酯类 红霉素、白霉素(吉他霉素)、罗红霉素、阿奇霉素、克拉霉素、乙酰螺旋霉素、麦迪霉素、交沙霉素等
4 酰胺醇类:包括氯霉素、甲砜霉素等
5 四环素类:包括四环素、土霉素(强力霉素)、金霉素等
6 林可酰胺类 克林霉素、林可霉素
7.糖肽类抗生素: 比如万古霉素、替考拉宁
8 抗真菌抗生素:如灰黄霉素、两性霉素B
9 抗肿瘤抗生素:如丝裂霉素、放线菌素D、博莱霉素、阿霉素等
10 具有免疫抑制作用的抗生素如环孢霉素
11 多磷类抗生素:如磷霉素

