BiologicalActivity
Inducerofapoptosis;displayspotentantitumorABIlityinhumanhepatocellularcarcinoma.Inhibitstubulinpolymerizationinvitroandinvivo.CausescellcyclearrestatG2/MphasebyactivationofCdc2kinaseactivity.Inducestranslocationofapoptosisinducingfactor(AIF)fromthemitochondriatonucleus.Alsoexhibitsvasculartargetingactivitythroughupregulationofp53andinductionofdeathreceptor(DR5)-mediatedapoptosisinHUVECcells.
TechnicalData
| M.Wt | 283.25 |
| Formula | C16H10FNO3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 154554-41-3 |
| PubChemID | 375860 |
| InChIKey | ZMYDAPJHGNEFGQ-UHFFFAOYSA-N |
| Smiles | O=C2C=C(C3=CC=CC=C3F)NC1=CC4=C(OCO4)C=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight283.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.53mL | 17.65mL | 35.3mL |
| 5mM | 0.71mL | 3.53mL | 7.06mL |
| 10mM | 0.35mL | 1.77mL | 3.53mL |
| 50mM | 0.07mL | 0.35mL | 0.71mL |
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