BiologicalActivity
Adenosinedeaminase(ADA)-resistantanalogofdeoxyadenosine.Exhibitsanti-leukemicactivity;Inhibitscellgrowthoflymphoidandmyeloidneoplasm(IC50=20-87nM).Pro-apoptotic;inducesDNAdouble-strandbreaks.Alsoinhibitsribonucleasereductase(IC50=0.11-0.28μM).Displaysactivityinvitroandinvivo.Orallybioavailable.
TechnicalData
| M.Wt | 285.69 |
| Formula | C10H12ClN5O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 4291-63-8 |
| PubChemID | 20279 |
| InChIKey | PTOAARAWEBMLNO-KVQBGUIXSA-N |
| Smiles | OC[C@H]1O[C@@H](N2C=NC3=C2N=C(Cl)N=C3N)C[C@@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.57 | 100 | |
| water | 1.43 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight285.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.5mL | 17.5mL | 35mL |
| 5mM | 0.7mL | 3.5mL | 7mL |
| 10mM | 0.35mL | 1.75mL | 3.5mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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