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Description:Antitumor,anti-inflammatoryandantioxidant
AlternativeNames:Diferuloylmethane
ChemicalName:(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptADIene-3,5-dione
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Antitumor,anti-inflammatoryandantioxidantagent.Downregulatesexpressionofreactive-oxygen-generatingenzymes(cyclooxygenase,lipoxygenase,iNOS),TNFα,IL-1,IL-6,PKC,EGFR,NF-κB,IκBkinaseandmore.UpregulatesexpressionofPPARγ,p53,Nrf2.Alsodisplaysantimicrobial,antidiabeticneuro-andcardioprotectivepropertiesinvivo.
TechnicalData
M.Wt | 368.38 |
Formula | C21H20O6 |
Storage | Storeat-20°C |
CASNumber | 458-37-7 |
PubChemID | 969516 |
InChIKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
Smiles | O=C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)/C=C/C1=CC(OC)=C(O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.68 | 10 | |
ethanol | 1.84 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight368.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.71mL | 13.57mL | 27.15mL |
5mM | 0.54mL | 2.71mL | 5.43mL |
10mM | 0.27mL | 1.36mL | 2.71mL |
50mM | 0.05mL | 0.27mL | 0.54mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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