BiologicalActivity
Nitrogenmustardalkylatingagentandprodrug.Phosphoramidemustard(activemetabolite)formsDNAcross-linksleADIngtocelldeath.Inhibitsaldehydedehydrogenase1(ALDH1)throughitsdegradationproductacrolein.Chemotherapeuticforthetreatmentofbreastcancer;regulatesBaxandBcl-2expressionwhenadmiNISTeredwithetoposide(Cat.No.1226)inbreastcancercelllines.
TechnicalData
| M.Wt | 261.09 |
| Formula | C7H15Cl2N2O2P |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 50-18-0 |
| PubChemID | 2907 |
| InChIKey | CMSMOCZEIVJLDB-UHFFFAOYSA-N |
| Smiles | O=P1(N(CCCl)CCCl)OCCCN1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.11 | 100 | |
| water | 26.11 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight261.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.83mL | 19.15mL | 38.3mL |
| 5mM | 0.77mL | 3.83mL | 7.66mL |
| 10mM | 0.38mL | 1.92mL | 3.83mL |
| 50mM | 0.08mL | 0.38mL | 0.77mL |
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