BiologicalActivity
Potentinhibitorofendoplasmicreticulumassociatedproteindegradation(ERAD).Specificallytargetsthep97-associateddeubiquinatingprocess(PAD)andinhibitsataxin-3(atx3)-dependentdeubiquitination.AlsoinhibitsSec61-mediatedproteintranslocationattheER.Displayscytotoxicactivitypreferentiallyagainstcancercells;inducescelldeathviatheproapoptoticproteinNOXA.
TechnicalData
| M.Wt | 630.44 |
| Formula | C27H25Cl2N7O7 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 412960-54-4 |
| PubChemID | 23947580 |
| InChIKey | JTUXTPWYZXWOIB-LWWHHIEBSA-N |
| Smiles | O=C1N(C2=CC=C(Cl)C=C2)C(N(O)C(NC4=CC=C(Cl)C=C4)=O)C(C)(C)N1CC(N/N=C/C=C/C3=CC=C([N+]([O-])=O)O3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 63.04 | 100 | |
| ethanol | 3.15 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight630.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.59mL | 7.93mL | 15.86mL |
| 5mM | 0.32mL | 1.59mL | 3.17mL |
| 10mM | 0.16mL | 0.79mL | 1.59mL |
| 50mM | 0.03mL | 0.16mL | 0.32mL |
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