BiologicalActivity
Cell-permeable,non-peptideinhibitorofX-linkedinhibitorofapoptosis(XIAP)(IC50=4.1μMincompetitionbindingassaywithSmacpeptide);bindstotheBIR3domain,preventingXIAPinteractionwithcaspase-9andSmac.Inhibitscellgrowth,inducesapoptosisandactivatescaspase-9inprostatecancercells(IC504-6μM),buthasaweakereffectonnormalprostatecells(IC50=19-20μM).OvercomestheprotectiveeffectofXIAPonapoptosisinXIAP-transfectedJurkatcells.Anti-tumor,analgesicandanti-inflammatoryinvivo.
TechnicalData
| M.Wt | 294.39 |
| Formula | C17H26O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 550-24-3 |
| PubChemID | 3218 |
| InChIKey | IRSFLDGTOHBADP-UHFFFAOYSA-N |
| Smiles | OC=1C(=O)C(CCCCCCCCCCC)=C(C(=O)C1)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.44 | 100 | |
| ethanol | 2.94 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight294.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.4mL | 16.98mL | 33.97mL |
| 5mM | 0.68mL | 3.4mL | 6.79mL |
| 10mM | 0.34mL | 1.7mL | 3.4mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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