Tocris型号参数规格 Tocris Bioscience抗体品牌,Tocris/Gambogic acid/3590/10/10 mg,细胞凋亡,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/Gambogic acid/3590/10/10 mg

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Tocris

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3590/10

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4000-520-616

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Description:Apoptosisinducer.ActivatescaspasesandinhibitsBcl-2familyproteins

ChemicalName:(2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoicacid

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ApoptosisinducerinseveraltumorcelllinesincludingT47Dcells.Activatescaspases(EC₅₀valuesare0.78-1.64μM)andcompetitivelyinhibitsantiapoptoticBcl-2familyproteins(IC₅₀valuesare1.47,1.21,2.02,0.66,1.06and0.79μMforBcl-XL,Bcl-2,Bcl-W,Bcl-B,Bfl-1andMcl-1respectively).Reversesgefitinib-resistanceinmicebearingtumorswithEGFR-T790Mmutation.AlsoblocksK_ir2.1channels(EC₅₀≤100nM).

TechnicalData

M.Wt	628.75
Formula	C₃₈H₄₄O₈
Storage	Storeat-20°C
CASNumber	2752-65-0
PubChemID	15559465
InChIKey	GEZHEQNLKAOMCA-MYCCNKBCSA-N
Smiles	C/C(C)=C/CC[C@@](C=C2)(C)OC1=C2C(O)=C(C(C([C@]45O3)=C[C@H](C[C@@H]56)C([C@](OC(C)6C)4C/C=C(C(O)=O)/C)=O)=O)C3=C1C/C=C(C)/C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	47.16	75
	ethanol	62.87	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight628.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.59mL	7.95mL	15.9mL
5mM	0.32mL	1.59mL	3.18mL
10mM	0.16mL	0.8mL	1.59mL
50mM	0.03mL	0.16mL	0.32mL

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BiologicalActivity

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