BiologicalActivity
NaturallyoccurringflavonoidfoundinGingkobilobaandredwinesthatactivatesthemitochondrialCa2+uniporter(EC50=7μM).Inducescaspase-9-mediatedapoptosisinavarietyofcancercelllinesviadownregulationofpolo-likekinase1(PLK1)expression.Exhibitsantioxidantactivityandattenuatesosteoclasticbonereabsorptioninvitro.AlsoblocksEGF-inducedhistoneH3Ser10phosphorylationinmouseepidermalJB6C141cells.
CompoundLibraries
KaempferolisalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 286.24 |
| Formula | C15H10O6 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 520-18-3 |
| PubChemID | 5280863 |
| InChIKey | IYRMWMYZSQPJKC-UHFFFAOYSA-N |
| Smiles | O=C2C1=C(O)C=C(O)C=C1OC(C3=CC=C(O)C=C3)=C2O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.62 | 100 | |
| ethanol | 28.62 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight286.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.49mL | 17.47mL | 34.94mL |
| 5mM | 0.7mL | 3.49mL | 6.99mL |
| 10mM | 0.35mL | 1.75mL | 3.49mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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