BiologicalActivity
Apoptotic,antiproliferativeandantiangiogenicagent,invitroandinvivo;actsviaanestrogenreceptor-independentmechanism.Inducesp53-inducedapoptosisviatwopathways:activationofp38andNF-κB;andactivationofJNKandAP-1leADIngtoBcl-2phosphorylation.Alsoupregulatesdeathreceptor5andbindstotubulin,inhibitingitsassembly.
CompoundLibraries
2-MethoxyestradiolisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 302.41 |
| Formula | C19H26O3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 362-07-2 |
| PubChemID | 66414 |
| InChIKey | CQOQDQWUFQDJMK-SSTWWWIQSA-N |
| Smiles | OC1=C(OC)C=C2C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.12 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight302.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.31mL | 16.53mL | 33.07mL |
| 5mM | 0.66mL | 3.31mL | 6.61mL |
| 10mM | 0.33mL | 1.65mL | 3.31mL |
| 50mM | 0.07mL | 0.33mL | 0.66mL |
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