BiologicalActivity
Antitumoragentthatformsplatinum-DNAadducts.Causesintra-andinterstrandDNAcrosslinksblockingDNAreplicationandtranscription.Displayshighercytotoxicityandlowernephrotoxicitythananalogcisplatin(Cat.No.2251)andshowsantitumoractivityincelllineswithacquiredcisplatinresistance.
TechnicalData
| M.Wt | 397.29 |
| Formula | C8H14N2O4Pt |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 61825-94-3 |
| PubChemID | 9887054 |
| InChIKey | ZROHGHOFXNOHSO-BNTLRKBRSA-L |
| Smiles | [Pt++].[O-]C(=O)C([O-])=O.[H][C@@]1(N)CCCC[C@@]1([H])N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.99 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight397.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.59mL | 25.17mL |
| 5mM | 0.5mL | 2.52mL | 5.03mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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