BiologicalActivity
Inducescelldeathandincreasesthelevelofreactiveoxygenspecies(ROS)incancercellswithbothwild-typeandnormalp53.Alsoinhibitsthegrowthofspontaneousmalignantbreasttumorsinmice.Displayslittleeffectonnormalcells.RapidlydepletesandrogenreceptorexpressioninhumanprostatecancercellsviaaROS-dependent,proteasome-mediatedmechanism.
TechnicalData
| M.Wt | 317.34 |
| Formula | C17H19NO5 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 20069-09-4 |
| PubChemID | 637858 |
| InChIKey | VABYUUZNAVQNPG-BQYQJAHWSA-N |
| Smiles | O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.73 | 100 | |
| ethanol | 6.35 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight317.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.15mL | 15.76mL | 31.51mL |
| 5mM | 0.63mL | 3.15mL | 6.3mL |
| 10mM | 0.32mL | 1.58mL | 3.15mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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