正品Tocris生物试剂1 TOCRIS 4372-10MG,Tocris/AZD 5582 dihydrochloride/5141/50/50 mg,细胞凋亡,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/AZD 5582 dihydrochloride/5141/50/50 mg

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Tocris/AZD 5582 dihydrochloride/5141/50/50 mg

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Tocris

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5141/50

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4000-520-616

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Description:DimericSmacmimetic;potentIAPinhibitor

ChemicalName:3,3'-[2,4-HexADIyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DimericSmacmimetic;potentinhibitorofX-linked(XIAP)andcellular(cIAP)inhibitorofapoptosisprotein(IC₅₀valuesare15,15and21nMforXIAP,cIAP1andcIAP2respectively).BindstotheBIR3domainofXIAPtopreventinteractionwithcaspase-9.CausesdegradationofcIAP1andcIAP2andinducesapoptosisinMDA-MB-231breastcancercells.CausestumorregressioninMDA-MB-231xenograft-bearingmice.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd

TechnicalData

M.Wt	1088.21
Formula	C₅₈H₇₈N₈O₈.2HCl
Storage	Storeat-20°C
Purity	≥97%(HPLC)
PubChemID	90489014
InChIKey	DAILKFFMJFAUCE-GXSVUDMFSA-N
Smiles	CN[C@@H](C)C(N[C@@H]([C@H]1CCCCC1)C(N2[C@H]([C@](N[C@H]3C(C=CC=C5)=C5C[C@H]3OCC#CC#CCO[C@@H]4CC8=C(C=CC=C8)[C@@H]4N[C@@]([C@H](CCC7)N7C([C@H]([C@H]6CCCCC6)NC([C@H](C)NC)=O)=O)=O)=O)CCC2)=O)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	108.82	100
	water	108.82	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1088.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.92mL	4.59mL	9.19mL
5mM	0.18mL	0.92mL	1.84mL
10mM	0.09mL	0.46mL	0.92mL
50mM	0.02mL	0.09mL	0.18mL

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