BiologicalActivity
BindsandstabilizesG-quadruplexes,inducingDNAdamageandcellcyclearrest(Kd=490nM);targetstheproto-oncogeneSrc,reducingSrcproteinabundanceandSrc-dependentmotilityinhumanbreastcancercells.AlsotargetstelomericG-quadruplexes,inducingtelomerasedysfunction.ActivatestheDNA-dependentproteinkinasecatalyticsunbunit(DNA-PKcs).
TechnicalData
| M.Wt | 778.94 |
| Formula | C31H32N8O5.5HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| PubChemID | 78243739 |
| InChIKey | SRIZPFGTXSQRFM-UHFFFAOYSA-N |
| Smiles | NCCOC1=CC(C(NC2=NC(C=CC=C3)=C3C(OCCN)=C2)=O)=NC(C(NC4=CC(OCCN)=C(C=CC=C5)C5=N4)=O)=C1.Cl.Cl.Cl.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 77.89 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight778.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.28mL | 6.42mL | 12.84mL |
| 5mM | 0.26mL | 1.28mL | 2.57mL |
| 10mM | 0.13mL | 0.64mL | 1.28mL |
| 50mM | 0.03mL | 0.13mL | 0.26mL |
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