

Overview:
TRKA is a member of the trk proto-oncogene family and encodes a 140kDa, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2).
Gene Aliases:
NTRK1; MTC; TRK; TRK1; p140-TrkA
Genbank Number:
NM_002529
References:
1. Kaplan, D R. et al: The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science. 1991 Apr 26;252(5005):554-8. 2. Boissiere, F. et al: Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease. Mol Chem Neuropathol. 1996 May-Aug;28(1-3):219-23.
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(第1张图和第2张图是经旋转后方向恰好相反的两张图,上矢状窦等静脉也显示了)
女患,70岁,大专毕业,我院退休药师。7-8年前患脑梗(具体不详)。记忆力差5-6年,近记忆为著,几次做饭后忘记关火,将炉具的台板(玻璃的)烧裂。近5-6年来,病人每年住院彻底检查治疗1次(主要是使用活血化瘀及营养脑细胞药)。平素,病人双耳听力略差,睡眠欠佳、便秘、尿频,偶从卧位坐起时视蒙。既往有时血压略高,未降压治疗。本次为“通血管”再来住院。查体:血压:140/80mmHg,双耳听力略差,近记忆力差,但智力(MMSE:26分)正常,颅神经未见异常,四肢肌力、感觉未见异常,植物神经未查,双掌颌反射(+),双下肢病理反射均阴性。血常规:淋巴细胞比率略高,余均正常;尿常规、心电图、癌胚抗原均正常;凝血四项:除凝血酶时间略长外均正常;生化全项:除总胆固醇略高外均正常;超声心动图:老年瓣退行性改变,左室舒张功能减退,房膜瘤可能。彩超:双侧颈动脉粥样硬化形成。头MRA:右大脑中动脉及其分支未显示。
问题:1MRI怎么会这样逍遥?病人无肢体瘫,生活自理如常人。
2为明确头MRA:右大脑中动脉及其分支未显示的病因和程度,除做DSA外,还需做什么?
3如不做DSA,给他订类药、阿斯匹林及活血化瘀的中药可不可以?
教。
版主laocao留言:
患者的年龄,病史,症状,辅助检查传上来,便于进一步讨论,谢谢!

