| Product Name | SensoLyte® 520 Meprin β Activity Assay Kit *Fluorimetric* |
| Size | 1 kit |
| Catalog # | AS-72254 |
| US$ | $526 |
Meprin β, a type I transmembrane metalloprotease, belongs to the astacin family of zinc endopeptidases and the metzincin superfamily. Protein expression has been identified in multiple tissues and cell types such as kidney, intestine, skin, leukocytes and several cancer cells. Though the biological function of Meprin β is not fully understood, it was found that Meprin β plays various roles in inflammatory response, collagen assembly, cancer progression and β-amyloid protein cleavage. More growing evidence has indicated that Meprin β is a good therapeutic target in regulating angiogenesis, cancer, inflammation, fibrosis, and neurodegenerative diseases.The SensoLyte® 520 Meprin β Activity Assay Kit can be used to detect enzyme activity in purified enzyme preparations and compound screening. The unique FRET substrate was derived from APP sequence designed to reduce the cross reactivity with Meprin α, ADAM10, α-secretase, BACE-2, IDE and ECEs, Neprilysin and TACE. Active Meprin β cleaves the FRET substrate resulting in an increase of 5-FAM fluorescence, that can be monitored at excitation/emission = 490 nm/520 nm. The long wavelength fluorescence of 5-FAM is also less interfered by the autofluorescence of components in biological samples and test compounds. This assay can detect as low as 0.048 ng/mL active Meprin β.The kit contains: 5-FAM/QXLᵀᴹ 520 Meprin β substrate, Ex/Em=490/520 nm upon cleavage Assay buffer Recombinant Human Meprin β Meprin β activation buffer Meprin β stop solution Inhibitor Fluorescence reference standard for calibration A detailed protocol Kit size: 100 assays (96-well plate)Figure 1.Inhibition of Meprin β activity by Actinonin as measured with SensoLyte® 520 Meprin β Activity Assay Kit.
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| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
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（第1张图和第2张图是经旋转后方向恰好相反的两张图，上矢状窦等静脉也显示了）
女患，70岁，大专毕业，我院退休药师。7-8年前患脑梗（具体不详）。记忆力差5-6年，近记忆为著，几次做饭后忘记关火，将炉具的台板（玻璃的）烧裂。近5-6年来，病人每年住院彻底检查治疗1次（主要是使用活血化瘀及营养脑细胞药）。平素，病人双耳听力略差，睡眠欠佳、便秘、尿频，偶从卧位坐起时视蒙。既往有时血压略高，未降压治疗。本次为“通血管”再来住院。查体：血压：140/80mmHg,双耳听力略差，近记忆力差，但智力（MMSE：26分)正常，颅神经未见异常，四肢肌力、感觉未见异常，植物神经未查，双掌颌反射（+），双下肢病理反射均阴性。血常规：淋巴细胞比率略高，余均正常；尿常规、心电图、癌胚抗原均正常；凝血四项：除凝血酶时间略长外均正常；生化全项：除总胆固醇略高外均正常；超声心动图：老年瓣退行性改变，左室舒张功能减退，房膜瘤可能。彩超：双侧颈动脉粥样硬化形成。头MRA:右大脑中动脉及其分支未显示。
问题：1MRI怎么会这样逍遥？病人无肢体瘫，生活自理如常人。
2为明确头MRA:右大脑中动脉及其分支未显示的病因和程度，除做DSA外，还需做什么？
3如不做DSA，给他订类药、阿斯匹林及活血化瘀的中药可不可以？
教。
版主laocao留言:
患者的年龄，病史，症状，辅助检查传上来，便于进一步讨论，谢谢！
