请使用支持JavaScript的浏览器! affinity biologicals/Protein S Polyclonal Antibody - Sheep/SAPS-IG_蚂蚁淘,【正品极速】生物医学科研用品轻松购|ebiomall 蚂蚁淘商城
商品信息
联系客服
affinity biologicals/Protein S Polyclonal Antibody - Sheep/SAPS-IG
郑重提醒:
无质量问题不接受退换货,下单前请仔细核对信息。
下单后请及时联系客服核对商品价格,订单生效后再付款。
affinity biologicals/Protein S Polyclonal Antibody - Sheep/SAPS-IG
品牌 / 
affinity
货号 / 
SAPS-IG
美元价:
(友情提示:该价格仅为参考,欢迎联系客服询价!)
数    量:
免费咨询热线
4000-520-616

Description

Protein S Polyclonal Antibody – Sheep

Affinity’s Protein S Polyclonal Antibody – Sheep is the base level of our Protein S antibody family.  The purity of IgG is typically 90% and is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v).  The titre is essentially the same as the starting antiserum and each vial typically contains the amount of IgG recovered from one milliliter of antiserum.  This Protein S Polyclonal Antibody – Sheep is generally intended for use in applications such as immuno-precipitation, immuno-electrophoresis, immuno-depletion and activity neutralization assays.


Product Code: SAPS-IG

Retail Product Size: 10mg vial

Host Animal: Sheep Anti-Human Protein S Polyclonal Antibody – Sheep

Species Cross Reactivity: View Chart

Product Datasheet: Protein S PS Polyclonal Antibody, purified anti-human sheep IgG


Description of Protein S

Protein S is a vitamin K-dependent glycoprotein produced in the liver, endothelium and megakaryocytes. The concentration of PS in plasma is ~25 μg/ml (~325 nM) where it acts as a cofactor in the anticoagulant activity of activated Protein C. A deficiency of Protein S (quantitative or qualitative) is a risk factor for vascular thrombosis. Protein S is expressed as a single chain molecule with a molecular weight of 77 kDa. The structure of PS is similar to many other vitamin-K dependent coagulation proteins, consisting of an N-terminal calcium binding domain of 10 γ-carboxyglutamic acid (gla) residues, followed by a thrombin-sensitive loop region and 4 EGF-like domains. The C-terminal domain does not contain the usual catalytic triad of a proenzyme, but seems instead to be involved in the binding of PS to C4b-binding protein (C4bp). Protein S binds to activated Protein C (APC) in the presence of calcium and negatively charged phospholipid surface to allow APC to proteolytically inactivate coagulation cofactors Va and VIIIa. Enzymatic regulation of PS cofactor activity is through cleavage of PS in the thrombin-sensitive loop region by thrombin or other enzymes, resulting in the loss of calcium binding properties and APC cofactor activity. Another regulatory mechanism is to reduce the availability of PS by the binding of PS to C4bp. In plasma, approximately 60% of Protein S circulates in non-covalent complex with C4bp, making it unavailable for APC cofactor activity. The binding of PS to C4bp may be important in localizing C4bp to damaged cell membranes where it may control activation of complement by the classical pathway1-3.

References and Review

  1. Broze GJ, Miletich JP; Biochemistry and Physiology of Protein C, Protein S and Thrombomodulin; in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp 259-276, J.B. Lippincott Co., Philadelphia PA, USA, 1994.
  2. Comp PC, Doray D, Patton D, Esmon CT; An Abnormal Plasma Distribution of Protein S Occurs in Functional Protein S Deficiency. Blood 67, pp 504-508, 1986.
  3. Schwalbe RA, Dahlback B, Nelsestuen GL; Independent Association of Serum Amyloid P Component, Protein S and Complement C4b with C4b-binding Protein and Subsequent Association of the Complex with Membranes; JBC 265, pp 21749-21757, 1990.
蚂蚁淘电商平台
ebiomall.com
公司介绍
公司简介
蚂蚁淘(www.ebiomall.cn)是中国大陆目前唯一的生物医疗科研用品B2B跨境交易平台, 该平台由多位经验丰富的生物人和IT人负责运营。蚂蚁淘B2B模式是指客户有采购意向后在蚂蚁 淘搜索全球供应信息,找到合适的产品后在蚂蚁淘下单,然后蚂蚁淘的海外买手进行跨境采购、 运输到中国口岸,最后由蚂蚁淘国内团队报关运输给客户...
蚂蚁淘承诺
正品保证: 全球直采 在线追溯 蚂蚁淘所有产品都是自运营的,我们已经跟国外多家厂方建立品牌推广合作关系, 获得对方的支持和授权; 同时客户可以通过订单详情查看到货物从厂方至客户的所有流程, 确保货物的来源; 正规报关,提供13%增值税发票。
及时交付: 限时必达 畅选无忧 蚂蚁淘的运营团队都是有着多年经验的成员,他们熟悉海外采购、仓储物流、报关等环节; 同时通过在线的流程监控,蚂蚁淘的进口速度比传统企业提高了50%以上, 部分产品甚至能做到7-10天到货,即蚂蚁淘的“时必达”服务。
轻松采购: 在线下单 简单省事 蚂蚁淘的价格是真实透明的,并且具有很大的价格优势,不需要繁杂的询价比价; 报价单与合同可以直接在线生成或打印;就像在京东购物一样, 您的鼠标点击几 次即完成在蚂蚁淘的采购,订单详情会告诉您所有进程。
售后申请: 耐心讲解 优质服务 蚂蚁淘提供的产品在使用过程中如因产品质量问题有售后需求时, 您可通过我的订单提交您的“申请售后”, 蚂蚁淘产品顾问会第一时间为您处理, 在售后服务过程中如遇到问题也可致电蚂蚁淘客服热线:4000-520-616。
7月1日,由江苏苏州市计量测试院作为第二起草单位制定的GB/T 36066-2018《洁净室及相关受控环境检测技术分析与应用》正式实施。检测项目《洁净室及相关受控环境检测技术分析与应用》给出了洁净室及相关受控环境的检测(包括验证)要求、基本仪器配置和技术要求,规定了制药、医疗、电子、科学实验室等不同应用领域的检测要求,适用于洁净室及相关受控环境的检测技术分析与应用。本标准共规定制药、医疗、科学实验室、电子四个运营领域常规检测项目。检测具备条件主要有过滤器出厂检漏合格以及净化机组完成吹扫测试,其 查看更多>
北京艾凡鹏有限公司在发布的洁净车间专用750Pa差压表GMP压差表浏阳星沙洁净检测压差计供应信息,浏览与洁净车间专用750Pa差压表GMP压差表浏阳星沙洁净检测压差计相关的产品或在搜索更多与洁净车间专用750Pa差压表GMP压差表浏阳星沙洁净检测压差计相关的内容。 查看更多>
广州英伦净化工程公司是华南地区空气净化工程、无尘车间、洁净室行业的龙头企业,系集无尘净化工程,无尘车间装修,洁净室,无尘室,gmp净化厂房,洁净厂房,gmp洁净车间,净化车间等空调洁净工程的设计施工及服务于一体的洁净室行业系统解决方案提供商。" />