Description:
DISCONTINUED–REPLACEMENT:MP0240
Multiplate®RISTOtestisaresearchreagentkitforthequantitativeinvitrodeterminationofvonWillebrandFactor(vWF)-andglycoproteinIb(GpIb)-dependentplateletaggregationstudiesontheMultiplate®analyzer.
RistocetinisanantimicrobialsubstancewhichformscomplexeswithvWF(vonWillebrandfactor).Inthiscomplex,vWFchangesitsconformationinawaythatallowsittobindtoplatelets.Thebindingofristocetin-vWFcomplexesleadstotheaggregationandactivationofplatelets.ThisactivationreliesonthebindingofvWFtotheGPIbreceptoranditisinhibitedbytheactionofAspirin®.ThisexplainstheAspirin®sensitivityofRISTOtest.CompletelackofaggregationintheresearchRISTOhightestcanbecausedbyanabsenceofGPIbreceptorsontheplateletsurface(Bernard-Souliersyndrome)orbyanabsenceofvWFinthesolution(vWDtypeIII).
KitComposition:
Reagents,StorageandStABIlity
- MP0140:Multiplate®RISTOtestReagent,Kit,Ristocetin,1x1.0mL, lyophilized(10mg/ml),with5microtesttubesfor aliquotation.UnopenedvialsoftheRISTOtestreagentmustbestored at2-8°C.Thereagentisstableuntiltheexpirydate printedontheviallabelwhenstoredunderthese conditions.Ifreconstitutedreagentisnotaliquotedinto microtesttubes,theoriginalvialshouldbestoredinan uprightposition. Stable7daysafterreconstitutionwhenstoredat 2-8°C, 4weeks at<-20°Cor24hoursatroomtemperatureafterone timethawing.
AlsoAvailable
- MP0094: Multiplate®RISTOtestAliquotVials,Bag, 100microtubescolorcoded(blue)forfor aliquotation.
- MP0194:Multiplate®RISTOtestReagent,Bag, Ristocetin,1x1.0mL, lyophilized(10mg/ml),withoutmicrotesttubesfor aliquotation.
- MP0240:Multiplate®RISTOtestReagent,Kit,Ristocetin,3x1.0mL, lyophilized(10mg/mL),withoutmicrotesttubesfor aliquotation.
MeasurementPrinciple:
RISTOtestreagentcontainsristocetin.Ristocetinformsa complexwithvWFfromthesample.Thiscomplexbinds totheplateletGpIbreceptorandtriggersplatelet activationandaggregation.RISTOtestcanbeappliedin twoconcentrations:InRISTOhightestahigh concentrationofristocetin(0.77mg/mL)isapplied,which normallyinducesastrongplateletaggregation.Abolished aggregationinRISTOhightestcanbebasedona deficiencyofGpIbreceptorsorvWF.InRISTOlowtesta lowerconcentrationofristocetin(0.2mg/mL)isapplied whichnormallydoesnotinduceastrongaggregation response.Ahigherthanexpectedaggregationin RISTOlowtestmayindicateanenhancedaggregation tendencyofvWF(vWDtypeIIb).
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最近要添加一些设备，请教各位大神推荐的厂家及其型号。
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先谢谢各位大神了
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下面上传《常用制剂设备》的图扫描。
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